In the recent past years, the 1,4-benzothiazine derivatives have been covering a large area of studying because of their synthetic possibility, different chemical behavior, there biological activities and different applications in the pharmaceutical drug. The 1, 4-benzothiazine forms an important class of heterocyclic system, it include the N and S molecules in the ring. The novel 1, 4-benzothiazine derivatives occupancy several biological activities such as anti-inflammatory, anti-rheumatic, antimicrobial, antioxidant, anti-hypertensive, anti-HIV, cardiovascular, ATP-sensitive potassium channel opener, anti-malarial, cytotoxic, immunomodulator, neuroprotective and aldose reductase inhibitor etc.
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